Jonathan Weinstein, MD, gives an overview of the complex topic of cerebrovascular diseases of white matter by discussing current medical cases, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infercts and leukoencephalopathy) as a medical diagnosis, Collagen Type 4A1 Mutations (Col4A1), cerebral amyloid angiopathy (CAA), a practical approach to white matter disease management and some genetic Leukoencephalopathies that may present in adulthood.